Increased Glucose Activity in Subgenual Anterior Cingulate and Hippocampus of High Performing Older Adults, Despite Amyloid Burden

Background: Individuals at 80 years of age or above with exceptional memory are considered SuperAgers (SA), an operationalized definition successful cognitive aging. SA showed increased thickness and altered functional connectivity in the anterior cingulate cortex as a neurobiological signature. However, their metabolic alterations yet to be uncovered. Objective: Herein, (FDG-PET), amyloid (PIB-PET), (fMRI) analysis were conducted. Methods: Ten SA, ten age-matched older adults (C80), cognitively normal middle-aged (C50) underwent testing multimodal neuroimaging examinations. Anterior posterior regions hippocampal areas primarily examined, then subregions segregated. Results: The group activity left right subgenual (sACC, p < 0.005 corrected, bilateral) bilateral hippocampi (right: 0.0005 left: 0.005, both corrected) compared that C80 group. Amyloid deposition was threshold 30% (p > 0.05). also presented decreased between sACC Conclusion: These results support key role hippocampus even presence deposition. It suggests may used potential biomarker for ability. Further longitudinal studies measuring biomarkers help elucidate interaction these aging process.